Annual report pursuant to Section 13 and 15(d)

Unaudited Quarterly Financial Information - Schedule of Quarterly Financial Information (Detail)

v3.8.0.1
Unaudited Quarterly Financial Information - Schedule of Quarterly Financial Information (Detail) - USD ($)
3 Months Ended 12 Months Ended
Dec. 31, 2017
Sep. 30, 2017
Jun. 30, 2017
Mar. 31, 2017
Dec. 31, 2016
Sep. 30, 2016
Jun. 30, 2016
Mar. 31, 2016
Dec. 31, 2017
Dec. 31, 2016
Dec. 31, 2015
Quarterly Financial Information Disclosure [Abstract]                      
Revenue $ 29,135 $ 250,000 $ 299,506 $ 575,368 $ 129,786 $ 1,003,973 $ 181,818 $ 136,364 $ 1,154,009 $ 1,451,941 $ 2,500,000
Operating expenses 11,267,948 13,001,623 13,220,879 13,051,387 14,744,905 11,131,994 10,468,990 10,936,772 50,541,837 47,282,661 30,077,339
Net loss $ (11,236,477) $ (12,748,248) $ (12,919,010) $ (12,473,140) $ (14,611,234) $ (10,125,063) $ (10,284,555) $ (10,796,542) $ (49,376,875) $ (45,817,394) $ (27,561,702)
Loss per share, basic and diluted $ (0.50) $ (0.58) $ (0.63) $ (0.61) $ (0.75) $ (0.57) $ (0.62) $ (0.66) $ (2.31) $ (2.60) $ (2.07)